Monday, February 27, 2012

Putin assassination plot: opposition, security experts cast doubt

Russian and Ukrainian security services say they thwarted an assassinate plot against presidential candidate Vladimir Putin. Some critics see politics in the announcement's timing.

Russian and Ukrainian security services announced Monday that they have thwarted an attempt by Chechen militants to assassinate Vladimir Putin after next Sunday's vote, in which he is expected to be elected as Russia's president.

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The plot's exposure, coming on the eve of elections in which Mr. Putin is under great pressure to pull off a convincing first-round victory, has prompted predictable skepticism from the opposition. Even some security experts say the timing seems a bit fishy, and the conspiracy, as explained on state TV, somewhat too vague to be thrust into the day's news headlines.

A video?broadcast on the state-run Channel One Monday showed Chechen terrorist suspect Adam Osmayev, with a badly battered face, confessing that he and two accomplices had been sent to Odessa, in Ukraine, to prepare for the attack.

"The final task was to go to Moscow and carry out an assassination attempt on Prime Minister Putin," Mr. Osmayev is shown saying. "The deadline was set up for the period after the presidential elections."

The report said that the men were detained in Odessa last January after a blast in a rented apartment, apparently caused by a homemade bomb, killed one of the gang. The other two, under interrogation by Ukrainian security forces, admitted they had been sent by Chechen Islamist warlord Doku Umarov?to research and equip for the assassination attempt on Putin.

The plan reportedly involved striking Putin's motorcade with powerful "anti-tank mines" planted along the side of Moscow's central Kutuzovsky Prospekt, which is part of Putin's regular route to work as he travels from his home, near the Moscow-region town of Usovo, to government headquarters each day.?According to the report, the suspects had information about Putin's daily habits on a laptop computer, including videos of his motorcade shot from different angles.

Experts say that such an attack would be extremely difficult. The entire route between Putin's suburban home and his office is usually completely closed down and cleared of traffic. The streets are patrolled by police cruisers and security agents are posted every few-hundred yards, before Putin even begins moving. When he does move, it is always in a convoy of several armored cars that typically tears along the empty roads at speeds of about 150 miles per hour.

"What we're hearing doesn't really sound like something well-planned and conceived, but more like somebody's ambition," says Andrei Soldatov, editor of the online journal Agentura.ru, which reports on security issues, and co-author of The New Nobility, a new book about Russia's secret services.

"It's not clear why this needed to be made public today," he adds.

The state-owned English-language TV network RT quoted Viktor Ozerov,?the head of the Kremlin-appointed, upper parliamentary house's defense and security committee, as saying that Putin is a perennial target of terrorists. "All Vladimir Putin?s actions ? have been aimed at fighting with bandit formations, organized crime, and terrorism," he said. "Putin has stepped on the throat and tail of many a terrorist and this is why the preparations for such terrorist attack are hardly a surprise."

But political experts say the timing of the announcement looks more like an election ploy than serious news.

"It sounds like complete nonsense and bluff," says Stanislav Belkovsky, president of the independent Institute of National Strategy in Moscow. "The real threat is that Putin looks like he might get less than 40 percent of the votes, when he needs 20 percent more for a convincing victory. So, obviously they're throwing in everything to ensure he'll win in the first round."

Yury Kobaladze, a former KGB agent who's now a businessman, says it even makes poor politics.

"I haven't had anything to do with the special services for some time, but as a citizen, I think the timing chosen for this news is all wrong," he says. "It won't influence Putin's supporters, but it will give the opposition a chance to criticize by saying it's all nonsense."

Mr. Soldatov points out that officials have announced several previous attempts on Putin's life, and all such declarations have been followed by silence.

"I think we can count about 12 previous occasions in which security officials have said they thwarted a plot to kill Putin, some of them outside of Russia in former Soviet countries," he says. "Yet we have never seen a single trial of suspects take place. Not one. We have no idea what happened to the alleged perpetrators of these plots. That's really odd."

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/MK8KLriexDI/Putin-assassination-plot-opposition-security-experts-cast-doubt

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marrathon: Found article @iMore: "How to take great looking portraits with your iPhone camera" http://t.co/E9zzIJph

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Sunday, February 26, 2012

Outsource Business to business telemarketing on Lead Generation ...

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The main purpose of Prospecting is for an organization to expand it?s market share via reaching the particular high-level decision producers of establishments involved inside of its goal industry. Most Lead experts are well competent in discovering the needs of the particular prospects and also inspire the particular prospect?s executives to employ the business to business telemarketing call center to help the prospective customers produce competent leads and hang up appointments using the company?s income teams. Outsourcing techniques the lead course of action increases the company?s revenue and earnings while decreasing the cost for every sale bills. Outsourced Prospecting also gets rid of a challenging supervision process. The main reason for outsourcing telemarketing solutions is that telephone selling call centers increase effective product sales orientation procedures to get the best benefits from the market. Prospecting campaigns have to be done continually to temperature market trend shifts and also changes in the international market overall economy.

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After creating the lead requirements, a company?s marketing consultant must know his / her lead supply. He must have the ability to identify your sources of leads and be able to begin using these efficiently and effectively for you to routinely construct leads and also continuously up-date the prospects list these people currently have.

If a company makes a decision to hire their particular team regarding lead phone callers, they must be willing to train their own staff about phone social manners, identifying the particular prospects in addition to their questions and also issues in connection with service being offered. Also, an organization must be willing to put up a workplace specifically designed for the lead generation telemarketers. They have to also device a fool-proof income script in whose pitch looks personal but still has an component of sales and marketing involved.

When engaged in their own leads generation campaign, an organization may also find it fit to acquire their own computerized responder, like Live Chitchat, wherein prospect customers may well leave inquiry messages when they are unavailable to get hold of you using the phone. They may also abandon their contact information herein to ensure that you may be able to make contact with them the moment a representative can be acquired.

When offsite, Lead grows more effective and practical as compared with maintaining you use private personnel doing the job for you personally. For one, outsourcing lead generation telesales is a cost-efficient substitute for an otherwise pricey restructuring of the office and the packages and application to be used in the campaign. The customer may simply enroll in a month-long marketing campaign and has an opportunity to eliminate the relationship after the contract or proceed the strategy for a longer time.

Furthermore, the company should be able to save on the expenses of training which will otherwise be shouldered through the company if they decide to put by themselves team. Outsoucring Lead Generation campaigns maintain their unique training crew who have been doing lead activities for years and so are therefore professionals on the themes of set of scripts making, cell phone etiquette as well as convincing methods which will finally lead to a face-to-face session with a customer?s sales representative.

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It?s best to outsource leads generation should an established telesales call center or outbound telesales firms as these companies come with the latest engineering and the finest people to carry out the campaign in the manner which in turn clients expect from their very own team.

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Source: http://virtual-unified-communications.info/?p=1861&utm_source=rss&utm_medium=rss&utm_campaign=outsource-business-to-business-telemarketing-on-lead-generation-2

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The 2012 Buick Verano (The Week)

[unable to retrieve full-text content]The Week - What the critics say about GM's new Buick, which starts at $22,585.USA TodayNo vehicle is perfect, but “among premium small cars,” the Verano is “close enough.” Continuing an encouraging trend at the new Buick, the automaker’s first compact in years “drives so remarkably well that you crave more wheel time.” What’s more, the “seriously high-class interior” will make any driver “feel like somebody special.” Unfortunately, fuel economy disappoints. Highway consumption is supposedly 32 mpg, but in suburban driving our test Verano managed just 17 mpg.

Source: http://us.rd.yahoo.com/dailynews/rss/oped/*http%3A//news.yahoo.com/s/theweek/20120224/cm_theweek/224809

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Saturday, February 25, 2012

Video: Fears arise that Republicans are throwing the election away

Can you get addicted to ice cream? Maybe

Baskin-Robbins-as-crack-house might seem ridiculous, and the idea that any food can be addictive in the scientific sense is still controversial. But, broadly speaking, as far as the brain?s circuitry is concerned, pleasure is pleasure. Activation patterns often look about the same.

Source: http://www.msnbc.msn.com/id/3036697/vp/46504294#46504294

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Friday, February 24, 2012

Kathy Ireland Richest Supermodel: What Is She Worth?

Who knew? I have seen a ton of Kathy Ireland products over the years but I had no idea she was doing so well! According to Forbes, Kathy is worth an estimated $300 to $350 million making her the worlds richest supermodel! Get all the crazy deets at PopWatch. Here are my other TGIF links!! Have a good weekend peeps!! XO This is such a dumb reason to be arrested – dude doesn’t think…Arrest Warrant Prepared For Chris Brown – Have U Heard? Love this so much! How beautiful is Rachel McAdams? Friday?s Fabulous Fashionistas Are: Angelina Jolie, Rachel McAdams & More – I Need My Fix. Whitney Houston?s Drug Dealer Network Exposed – Celeb Dirty Laundry. Salma Hayek: Got Milk? – Celeb Gurlz. Today’s Warm Release; Sara Jean Underwood’s Sweet Bikini Tweet – The Great Monkey Suit. YUM – Ryan Gosling and his Piercing Blue Eyes for GQ Russia? – All Women Stalk. Danica Patrick Crash: Daytona 2012 Gatorade Duel PHOTOS, VIDEO – Bitten & Bound. 3 Pregnant Stars, Including Jessica Simpson, Who Are Ready To Give Birth – Girls Talkin’ Smack. Angelina Jolie On The Cover Of Be Magazine France February 2012 – Gossip and Soaps. Jennifer Aniston [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/EE2NgoZvJjY/

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7 states sue over Obama contraception rule

Seven states asked a federal judge Thursday to block an Obama administration mandate that requires birth control coverage for employees of religious-affiliated hospitals, schools and outreach programs.

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The lawsuit, filed in U.S. District Court of Nebraska, alleges that the new rule violates the First Amendment rights of groups that object to the use of contraceptives.

It marks the first legal challenge filed by states.

The rule, announced as part of the federal health care law, has come under fire from religious groups that object to the use of contraceptives, sterilization and abortion-inducing drugs. In response to the criticism, Obama administration officials have said they will shift the requirement from the employers to health insurers themselves.

The lawsuit was filed by attorneys general from Nebraska, Florida, Michigan, Ohio, Oklahoma, South Carolina and Texas. Three Nebraska-based groups ? Catholic Social Services, Pius X Catholic High School and the Catholic Mutual Relief Society of America ? are also plaintiffs in the lawsuit.

Story: Why birth control is pushing political buttons

Nebraska Attorney General Jon Bruning, a Republican who is running for U.S. Senate, said the administration's regulation "forces of millions of Americans to choose between following religious convictions and complying with federal law.

"We will not stand idly by while out constitutionally guaranteed liberties are discarded by an administration that has sworn to uphold them," he said.

The lawsuit alleges that the rule will effectively force religious employers and organizations to drop health insurance coverage, which will raise enrollment in state Medicaid programs and increase patient numbers at state-subsidized hospitals and medical centers.

The U.S. Department of Health and Human Services is named as a defendant. A phone message left with the agency on Thursday wasn't immediately returned.

The contentious issue has pushed social issues to the forefront in a presidential election year that has been dominated by the economy. Issues such as abortion, contraception and requirements of President Barack Obama's health care law have the potential to galvanize the Republicans' conservative base, which is critical to voter turnout in the presidential and congressional races.

The new policy has angered some religious groups, including the Roman Catholic Church, who say the requirement would force them to violate their stances against contraception. It has also drawn a sharp response from congressional Republicans.

Obama administration officials have said they don't want to abridge anyone's religious freedom, but want to give women access to important preventive care. Supporters of the rule, including the ACLU and women's advocacy groups, say the measure is about female health.

Republican lawmakers in a handful of states have seized on the contentious issue, presenting bills that would allow insurance companies to ignore the federal rules. Measures in Idaho, Missouri and Arizona would expand the exemptions to secular insurers or businesses that object to covering contraception, abortion or sterilization.

Officials have said the Obama administration's ruling was carefully considered, after reviewing more than 200,000 comments from interested parties and the public. The one-year extension, they said, responds to concerns raised by religious employers about making adjustments.

Administration officials stress that individual decisions about whether to use birth control, and what kind, remain in the hands of women and their doctors.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/46504140/ns/us_news-life/

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Thursday, February 23, 2012

Evangelist raises Obama faith issue again, 'has no idea' what president believes

Graham, who has led the?Billy?Graham?Evangelistic Association since his father's retirement, also repeated earlier remarks linking Obama to Islam through his African ancestry and said the Muslim world saw him as a Muslim.

Christian evangelist?Franklin?Graham, son of prominent preacher?Billy?Graham, stirred up the politically sensitive issue of President?Barack Obama's Christian faith on Tuesday, saying he accepted the president at his word that he was a Christian but he could not know what Obama actually believed.

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Graham, who has led the?Billy?Graham?Evangelistic Association since his father's retirement, also repeated earlier remarks linking Obama to Islam through his African ancestry and said the Muslim world saw him as a Muslim.

"That's just the way it works. That's how they see him. Of course, he says he didn't grow up that. He didn't believe in that. He believes in Jesus Christ. So I accept that," he said on MSNBC's "Morning Joe" program.

At another point in the interview, he said: "I have no idea what he really believes."

Earlier this month, Obama emphasized his Christian faith at a National Prayer Breakfast, saying he prayed every morning and has crafted key elements of his economic policies in line with Biblical teachings.

White House?spokesman?Jay Carney, asked about?Graham's comments on Tuesday, said the president was more focused on policy issues than on commentary about his personal faith.

Graham?said Obama's grandfather and father were Muslims. Obama himself has said although many people in his father's Kenyan village were Muslim, his father did not practice Islam and "wasn't very religious."

The issue of Obama's religious faith has already been raised in the campaign for the November presidential election, as potential Republican opponents assail his record and question his fitness to be re-elected for a second term.

One Republican hopeful, former?Pennsylvania?senator Rick Santorum, last week told supporters Obama's agenda was "about some phony ideal. Some phony theology. Oh, not a theology based on the Bible. A different theology." When asked about the statement later, Santorum said, "If the president says he's a Christian, he's a Christian."

Questions about Obama's religion by political opponents have sometimes been intertwined with discredited claims that he was born outside the?United States?and thus ineligible for the office.?Grahamhas aligned himself with that movement in the past.

Graham?said in Tuesday's interview: "I've told people this many times, I accept him at what he says. If he says he's a Christian, I accept that. I'm not going to say that he's not."

He raised no doubts about the religious commitment of Santorum and another Republican contender, former House of Representatives Speaker?Newt Gingrich. Both men are Catholics.

Speaking about another Republican candidate,?Mitt Romney, who is a Mormon,?Graham?said he would make "a good president" and said "he has the ability" to lead the country. When asked about Romney's Mormon faith,?Graham?said, "Most Christians would not recognize Mormonism as part of the Christian faith."

Billy?Graham?was among the most influential U.S. religious leaders of the 20th century, having prayed with every president since?Harry Truman. Obama visited?Billy?Graham?at his North Carolina home in 2010. ?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ZOeaCtRsm-o/Evangelist-raises-Obama-faith-issue-again-has-no-idea-what-president-believes

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Determing the best Home exercise space machines for a Health and ...

Posted by Sog on Feb 22, 2012 in Uncategorized | 0 comments

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Source: http://sogsweb.com/?p=417

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Wednesday, February 22, 2012

Eco-fraud: Global warming crusader admits lying, stealing, smearing (Michellemalkin)

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Southern Baptist leaders OK 'Great Commission' (AP)

[unable to retrieve full-text content]

FILE - In this Dec. 7, 2011 file photo, the headquarters of the Southern Baptist Convention is shown in Nashville, Tenn. The nation's largest protestant denomination will definitely remain 'Baptist,' but leaders are thinking about whether it will be 'Southern' for much longer. Southern Baptist Convention President Bryant Wright was expected to present the recommendation of a task force assigned to study a name change to the denomination's executive committee at a meeting Monday night, Feb. 20, 2012. (AP Photo/Mark Humphrey, File)AP - Some Southern Baptists worry that their denomination's name still carries the stigma of a 19th century split with northern Baptists over slavery. Others who fought hard to build the brand and its conservative theology and politics don't want to see it go.


Source: http://us.rd.yahoo.com/dailynews/rss/religion/*http%3A//news.yahoo.com/s/ap/20120221/ap_on_re/us_rel_southern_baptists_name

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Report: Myanmar desperate for HIV and TB drugs (AP)

[unable to retrieve full-text content]AP - Some 85,000 HIV-infected people in Myanmar are not getting treatment due to a lack of funding, despite renewed international engagement with the government amid a wave of political reform, according to a report released Wednesday.

Source: http://us.rd.yahoo.com/dailynews/rss/aids/*http%3A//news.yahoo.com/s/ap/20120222/ap_on_he_me/as_myanmar_hiv_treatment

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Tuesday, February 21, 2012

Enjoy Versatility and Comfort With Office Wireless Headphones ...

February 20th, 2012 | admin

Nathaniel Baldwin was the person behind the invention of wireless earbuds. Because of his tests with seem amplification utilizing compressed atmosphere, he could invent headsets which were later sold to the U.S. Navy before the World War I happened. A few more years later,two aircraft pilots created and developed a lightweight head set for aviation purposes only. The heavy and bulky headsets bothered a lot of aircraft pilots that they opted to return to the hand-held microphones for airline communication purposes.

These two pilots were the persons at the rear of the creation of Plantronics ? plantronics cs55 hl10, that is now one of the main headset manufacturing companies worldwide. Following being introduced to the commercial market, the innovated headsets became sought after not only in the aviation industry but also to the general users as well.

Comfort is the main purpose why Plantronics created the first lightweight headsets. A few years later, the organization experimented upon cordless headsets with the help of the then famous infrared technologies. To be able to connect the small transmitter to the base unit which was connected to the telephone network, the wireless head set utilized the infrared column. This very first wireless headset seemed to be the first ?echo-free? speaker phone that was used inside conference areas. The said mini transmitter might just be held by the hand or it could be clipped to the user?s top or shirt to make sure that the speaker?s voice is going to be clearly picked up.

Wireless headsets nowadays are very beneficial in the office. 1 perfect head set that could help to make an office staff more productive is Plantronics? Savi Workplace WO100 Wireless Headset Program.
It has a lot of unique features that could enhance the effectiveness and usefulness of an employee.

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Plantronics office wireless headsets offer the user a single voice marketing communications system with a longer wireless variety and life of the battery as well. Furthermore, these headsets also offer comfort and versatility, enabling user to easily change from one kind of sound or even gadget to another. Because of these functions, business owners can surely save a lot from this wireless headset system and he may even maximize their bottom line profit. Because Plantronics Savi Workplace is packaged with versatility and comfort, company will become much more productive and stress free.

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Source: http://alarmhungary.com/enjoy-versatility-and-comfort-with-office-wireless-headphones.dhtml

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NYC Public School Parents: The battle for the soul of a community ...

Nearly 500 parents, teachers, students, and community leaders filled the large auditorium, with more than 80 of them speaking out against this co-location proposal, and fewer than five parents from Brooklyn spoke out in support.? The rest of the audience consisted of parents bused in from the various Success charter schools in Harlem.??

And yet NYTimes/Schoolbook story ran a highly inaccurate and biased account, showing a large photo of the Success Academy parents, captioned with " parents turned out to support the co-location of a Success Academy charter school at J.H.S. 50 John D. Wells in Williamsburg, Brooklyn", without explaining that they were bused in by the charter operator from Harlem. The article went on to give most of its space to comments from the handful of supporters of the charter school, including the chain?s founder, Eva Moskowitz, with almost no mention of the huge outcry from the hundreds of community leaders, elected officials, and local parents who came out to oppose it. (Read the irate comments!)


....each day, the public school students would observe some 390 Beth Rachel students arrive at P.S. 16. The Beth Rachel students would be taught in classrooms only they may use; no public school students would be taught either in those classes or in those rooms. Yiddish would be spoken in the Beth Rachel classes. Only Hasidic girls would be taught; those girls would be allowed no contact with boys. Only female teachers would teach the Hasidic girls. And where once there was an open corridor allowing freedom to traverse the entire hall, there are now a wall and doors partitioning the Beth Rachel girls from the public school students....

The lengths to which the City has gone to cater to these religious views, which are inherently divisive, are plainly likely to be perceived, by the Hasidim and others, as governmental support for the separatist tenets of the Hasidic faith. Worse still, to impressionable young minds, the City's Plan may appear to endorse not only separatism, but the derogatory rationale for separatism expressed by some of the Hasidim.)
??

Source: http://nycpublicschoolparents.blogspot.com/2012/02/battle-for-soul-of-community-thursday.html

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Monday, February 20, 2012

Movie Review: Don't Get Burned By New GHOST RIDER Film (Newsarama.com)

[unable to retrieve full-text content]Newsarama.com - Hell hath no fury like a good comic book character scorned. If you were expecting Ghost Rider to receive a more dignified cinematic treatment the second time around, well... you got played. Ghost Rider: Spirit of Vengeance isn't as big a fiasco as say, Punisher: War Zone, but it's within a long chain's throw of it. A needlessly complicated story with senseless swerves, campy dialogue and some hammed-up acting by Nicolas Cage all combine to make for an experience that feels much longer than the 95-minute running time. ...

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/newsarama/20120220/en_newsarama/moviereviewdontgetburnedbynewghostriderfilm

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Intensity question for Romney stirs doubt for fall (The Arizona Republic)

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Sunday, February 19, 2012

Infantino Compact 2-in-1 Shopping Cart Cover

Sorry, Readability was unable to parse this page for content.

Source: http://evernano.com/infantino-compact-2-in-1-shopping-cart-cover/

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Factbox: Berlin film festival main competition (omg!)

(Reuters) - The Berlin film festival ends on Saturday with an awards ceremony.

Following is a list of the competition entries, the directors and main production countries. All are world premieres unless specified:

- "Barbara" by Christian Petzold, Germany

- "Bel Ami" by Declan Donnellan and Nick Ormerod, Britain (out of competition)

- "Caesar Must Die" (Cesare deve morire) by Paolo and Vittorio Taviani, Italy

- "Captive" by Brillante Mendoza, France/Philippines/Germany/Britain

- "Childish Games" (Dictado) by Antonio Chavarrias, Spain

- "Coming Home" (A moi seule) by Frederic Videau, France

- "Extremely Loud And Incredibly Close" by Stephen Daldry, U.S. (international premiere, out of competition)

- "Farewell My Queen" (Les Adieux la reine) by Benot Jacquot, France/Spain

- "The Flowers of War" (Jin ling Shi San Chai) by Zhang Yimou, China (European premiere, out of competition)

- "Flying Swords of Dragon Gate" by Hark Tsui, Hong Kong (European premiere, out of competition, 3D)

- "Home For the Weekend" (Was bleibt) by Hans-Christian Schmid, Germany

- "Jayne Mansfield's Car" by Billy Bob Thornton, Russia/U.S.

- "Just The Wind" (Csak a szl) by Bence Fliegauf, Hungary/Germany/France

- "Mercy" (Gnade) by Matthias Glasner, Germany/Norway

- "Meteora" by Spiros Stathoulopoulos, Germany/Greece

- "Postcards From the Zoo" (Kebun binatang) by Edwin, Indonesia/Germany/Hong Kong

- "A Royal Affair" (En kongelig affaere) by Nikolaj Arcel, Denmark/Czech Republic/Germany/Sweden

- "Shadow Dancer" by James Marsh, Britain/Ireland (European premiere, out of competition)

- "Sister" (L'enfant d'en haut) by Ursula Meier, Switzerland/France

- "Tabu" by Miguel Gomes, Portugal/Germany/Brazil/France

- "Today" (Aujourd?hui) by Alain Gomis, France/Senegal

- "War Witch" (Rebelle) by Kim Nguyen, Canada

- "White Deer Plain" (Bai lu yuan) by Wang Quan'an, China

Special Screenings:

- "Haywire" by Steven Soderbergh, U.S. (German premiere, special screening)

- "The Iron Lady" by Phyllida Lloyd (Meryl Streep received lifetime achievement Golden Bear)

(Source: www.berlinale.de)

(Reporting by Mike Collett-White;editing by Elaine Lies)

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_factbox_berlin_film_festival_main_competition100532377/44564335/*http%3A//omg.yahoo.com/news/factbox-berlin-film-festival-main-competition-100532377.html

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Friday, February 17, 2012

Elusive Greek bailout deal edges nearer (Reuters)

[unable to retrieve full-text content]Reuters - Greece edged closer on Friday to winning a new rescue package worth 130 billion euros ($170 billion) as officials said Germany was optimistic a deal could be struck despite misgivings over whether Athens would stick to commitments.

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/nm/20120217/bs_nm/us_greece

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Genetic mutation implicated in 'broken' heart

ScienceDaily (Feb. 15, 2012) ? For decades, researchers have sought a genetic explanation for idiopathic dilated cardiomyopathy (DCM), a weakening and enlargement of the heart that puts an estimated 1.6 million Americans at risk of heart failure each year. Because idiopathic DCM occurs as a familial disorder, researchers have long searched for genetic causes, but for most patients the etiology for their heart disease remained unknown.

Now, new work from the lab of Christine Seidman, a Howard Hughes Investigator and the Thomas W. Smith Professor of Medicine and Genetics at Harvard Medical School and Brigham and Women's Hospital, and Jonathan Seidman, the Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics at Harvard Medical School, has found that mutations in the gene TTN account for 18 percent of sporadic and 25 percent of familial DCM.

"Until the development of modern DNA sequencing platforms, the enourmous size of the TTN gene prevented a comprehensive analyses -- but now we know TTN is a major cause of DCM," said Christine Seidman, who reported the findings February 16 in the New England Journal of Medicine.

Idiopathic DCM is one of three different types of cardiomyopathy (the term "idiopathic" indicates that acquired causes for DCM such as atherosclerosis, excess drinking or viral infections have been excluded). It affects only about 4 in 10,000 Americans, but may be under-diagnosed because symptoms often appear late in the course of disease. DCM may cause shortness of breath, chest pain, and limited exercise capacity. DCM increases the risk of developing heart failure, for which no cure is available, and the risk of stroke and sudden cardiac death.

These findings will not only help patients understand the cause of their DCM symptoms, but also help to screen family members who might be at risk of developing the condition. Early identification of those at risk allows early intervention with medications that reduce workload on the heart and help prevent the changes in heart muscle, called remodeling, that lead to heart failure.

As DCM progresses, remodeling of the heart tissue makes the heart more prone to disturbances in the normal heart rhythm that can lead to stroke, heart attack and sudden death. "One of the added values to knowing that you are at risk for developing DCM is that we can do prophylactic screening so that silent arrhythmias are picked up before they become harmful," said Christine Seidman. "The discovery is immediately translatable into clinical practice to provide patients with gene-based diagnosis." The Partner's Laboratory for Molecular Medicine, an HMS affiliate, has incorporated TTN analyses.

The Seidmans and others had previously linked other gene mutations to about 20 to 30 percent of idiopathic DCM cases -- and, with more success, to a related disease, hypertrophic cardiomyopathy. They had examined almost all of the genes linked to muscle units known as sarcomeres, but saved the biggest for last: TTN, which encodes the protein titin. At approximately 33,000 amino acids, titin is the largest human protein.

"Titin was a missing link," said Christine Seidman. "A very large missing link."

The Seidmans' collaborated with researchers from the Imperial College (London) and the University of Washington. Traditional sequencing methods had previously found only a few TTN variants in patients with DCM because complete, accurate sequencing was too expensive.

Using next generation sequencing tools that substantially reduce the cost per base (the TTN sequence contains 100,000 bases) by orders of magnitude over earlier standards, the Seidmans were able to perform comprehensive screening for TTN mutations for the first time. They analyzed TTN in 312 DCM patients, 231 HCM patients, and 249 individuals with no disease.

Of the many mutations identified, 72 make the titin protein shorter.

Called TTN truncating variants, these specific mutations appeared almost exclusively in patients with DCM. "Our hypothesis is that any variant that shortens titin is going to cause DCM, which will lead to heart failure by the same mechanism," said Jonathan Seidman.

To identify the pathological mechanism, the Seidmans plan to model a handful of TTN truncating mutations in mice.

One concern in the search for disease causing genes is that, while there will be many gene variants discovered, only a few will cause disease. This is particularly true for missense mutations that cause single nucleotide changes -- changes that substitute a single amino acid within the protein.

"We often don't know if a missense mutation significantly impacts a protein's function, until we model it and study its effects," said Jonathan Seidman.

However, in the case of truncating mutations, "it's the converse," he continued. "We don't have to model all of those different mutations that truncate titin, becuase they all foreshorten the protein. We can pick a few representative ones and expect that they will reveal a common mechanism."

A better understanding of the mechanism may lead to better and more direct therapies for treatment and prevention of DCM.

This research was funded by Howard Hughes Medical Institute; National Institutes of Health; Leducq Foundation; American Heart Association and Muscular Dystrophy Association; and the UK National Institute for Health Research Cardiovascular Biomedical Research Unit.

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Story Source:

The above story is reprinted from materials provided by Harvard Medical School. The original article was written by Elizabeth Dougherty.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Daniel S. Herman, Lien Lam, Matthew R.G. Taylor, Libin Wang, Polakit Teekakirikul, Danos Christodoulou, Lauren Conner, Steven R. DePalma, Barbara McDonough, Elizabeth Sparks, Debbie Lin Teodorescu, Allison L. Cirino, Nicholas R. Banner, Dudley J. Pennell, Sharon Graw, Marco Merlo, Andrea Di Lenarda, Gianfranco Sinagra, J. Martijn Bos, Michael J. Ackerman, Richard N. Mitchell, Charles E. Murry, Neal K. Lakdawala, Carolyn Y. Ho, Paul J.R. Barton, Stuart A. Cook, Luisa Mestroni, J.G. Seidman, Christine E. Seidman. Truncations of Titin Causing Dilated Cardiomyopathy. New England Journal of Medicine, 2012; 366 (7): 619 DOI: 10.1056/NEJMoa1110186

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120215190144.htm

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Thursday, February 16, 2012

San Diego VOIP Provider Computer Support of San Diego Offers ...

San Diego VOIP Provider Offers Discount for Environmental Charities

(PRWEB) February 15, 2012

Computer Support of San Diego, a leading provider of San Diego IT Support, San Diego IT Consulting and San Diego IT Services has announced new discounted phone system pricing for environmental charities. Under the new plan, environmental charities will be eligible to benefit from discounts on the pricing of quality telephone system and telephony solutions available from Computer Support of San Diego. Phone system provider Computer Support of San Diego is a leader in telephone system products, VoIP Phones, hosted PBX solutions, Internet phone service, VoIP phone systems, Response Point phones, business telephone system solutions, conference phone systems, video surveillance equipment, VoIP gateways, telephony products and phone system support services to small businesses in the USA. Computer Support of San Diego will provide discounts to environmental charities on all phone system purchases made in 2012, and Computer Support of San Diego has asked interested organizations to contact the company for more information on how to take part in this new exciting program.

A socially responsible company, Computer Support of San Diego has positioned itself to assist environmental charities in promoting their goals and programs by ensuring that they are able to communicate effectively through the acquisition of highly subsidized high quality phone system equipment and other telephony services from Computer Support of San Diego. Computer Support of San Diego will now provide discounts to environmental charities to provide cost relief which can be channeled towards the furtherance of their activities.

The new plan from Computer Support of San Diego is likely to be a welcome offering in the light of the current economic climate. Environmental charities, as with any other organization whose finances are closely linked with member support, depend heavily on solid communications infrastructure to garner support for their programs and activities. In addition, volunteer efforts also play a key role in their financing. Modern and effective communications and telephone systems as a result, are more important than ever; with new systems facilitating remote users and collaboration more easily than in years past, especially through the use of Internet enabled telephone systems (VoIP- Voice over Internet Protocol).

To learn more about the San Diego VoIP solutions from Computer Support of San Diego, please call 858.384.0988 or visit our website at http://www.computersupportsandiego.com.

About Computer Support of San Diego

Computer Support of San Diego specializes in delivering enterprise class solutions for small and medium sized businesses through Southern California. From simple desktop support to large scale complex projects, our team of experienced and certified professionals are ready to assist. We offer solutions customized to each environment, ensuring that technology supports the business and works with existing processes. Because we are focused on delivering solutions to small businesses we are able to offer unprecedented flexibility and pricing. If you are looking for San Diego IT Consulting, San Diego IT Support or San Diego IT Services give us a call at (858)384-0989 or email sales(at)supportsd(dot)com.

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